There are an ever increasing number of dogs participating in activities that range from light workouts to strenuous exercise. These activities create an environment of metabolic stress. One system in charge of managing these stresses is the kidney and the rest of the urinary system. Understanding the basis of exercise-induced nephritis is important when developing a training regimen. The best way to prevent kidney damage and impairment is to train and condition athletic and working dogs to perform the activities associated with their work or competition.